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| Antigenic Specificity | CD274 (PD-L1, B7-H1) |
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| Clone | MIH5 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, lambda |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.06 µg/test |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), PE, eBioscience™. Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. |
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| Immunogen | n/a |
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| Other Names | B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1 |
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| Gene, Accession # | Entrez: 60533; Uniprot: Q9EP73 |
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| Catalog # | 12-5982-81 |
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| Price | |
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| Order / More Info | CD274 (PD-L1, B7-H1) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15238608, 15982311, 16478920, 17446350, 18272812, 18354211, 18559528, 18607390, 18719016, 19208362, 19276342, 19368976, 19417208, 19581626, 19741598, 20065112, 20427766, 20498261, 20653631, 21118528, 21159661, 21816363, 21873557, 21997806, 22022563, 22189788, 22266281, 22323540, 22641383, 22990670, 23159881, 23423360, 23656736, 23766529, 23798541, 23985377, 23986257, 24502656, 24554775, 24672679, 24696476, 25080485, 25246497, 25365203, 25370533, 25548274, 25695838, 25848866, 25941590, 25980009, 27156385, 27886180, 28212753, 28407484, 28479366, 28874817, 29246442, 29593314 |
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