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| Product Name | Recombinant Human X-ray repair cross-complementing protein 6 (XRCC6), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 28.8kDa. Partial: 6-222aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing th together. The assbly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku7070KDA subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1ATP-dependent DNA helicase II 70KDA subunitCTC box-binding factor 75KDA subunit; CTC75; CTCBFDNA repair protein XR; CC6Lupus Ku autoantigen protein p70; Ku70Thyroid-lupus autoantigen; TLAAX-ray repair complementing defective repair in Chinese hamster cells 6 |
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| Gene, Accession, CAS # | XRCC6, UniProt: P12956 |
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| Catalog # | RPC23971 |
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| Order / More Info | Recombinant Human X-ray repair cross-complementing protein 6 (XRCC6), partial from BIOMATIK |
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| Product Specific References | n/a |
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