| 产品详情 |
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| Product Name | PKI-179 (hydrochloride) |
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| Description | A dual PI3K and mTOR inhibitor; inhibits PI3K (IC50s = 8, 24, 17, and 74 nM for isoforms α, β, δ, and γ, respectively); inhibits PI3Kα mutants, E545K and H1047R (IC50s = 14 and 11 nM, respectively); inhibits mTOR (IC50 = 0.42 nM); antiproliferative against MDA-361 (breast) and PC3MM2 (prostate) cell lines (IC50s = 22 and 29 nM, respectively); inhibits tumor growth in MDA-361 mouse xenografts (50 mg/kg) |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1197160-28-3 PKI179 phosphatidylinositol-3 phosphoinositide 1634621-81-0 PI3Ka E-545K H-1047R CYP450 CYP-2C8 MDA361 PC3-MM2 human Ether-a-go-go-Related Gene antiproliferative anti-proliferative |
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| Gene, Accession, CAS # | CAS: 1463510-35-1 |
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| Catalog # | 21202-10 |
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| Price | |
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| Order / More Info | PKI-179 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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