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| Product Name | p27KIP1 Recombinant protein |
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| Description | MW: ~52 kDa. Recombinant full-length human p27KIP1 was expressed in E. coli cells using a N-terminal GST tag.Scientific Background: KIP1 (cyclin-dependent kinase inhibitor 1B) is a kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation (1). Many tumorigenic processes modulate cell-cycle progression by regulating the levels of the cyclin-dependent kinase inhibitor KIP1. KIP1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD |
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| Size | 0.02 mg, 0.05 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay, Western Blot (WB) |
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| Other Names | [CDKN1B; CDKN4; MEN1B] |
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| Gene, Accession, CAS # | p27KIP1, Gene ID: 1027, Accession: NP_004055.1 |
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| Catalog # | MBS515403 |
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| Order / More Info | p27KIP1 Recombinant protein from MYBIOSOURCE INC. |
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| Product Specific References | 1. Hoyt, M A. et al: Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 1992 118(1):109-120. 2. Carrano,A C. et al: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1999; 1, 193-199 |
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