| 产品详情 |
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| Product Name | Adapalene |
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| Description | A synthetic retinoid; an agonist of RARs (Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively); inhibits growth and differentiation of sebocytes in primary rat preputial cell culture; completely inhibits the activity of soybean 15-LOX in an enzyme assay at 10 µM; inhibits the 5- and 15-LOX pathways in human blood PMNs at 10 µM; reduces the protein levels of TLR2 and IL-10 in skin explants isolated from patients with acne as well as healthy controls; increases the expression of CD1d in acne skin explants while decreasing it in control explants; inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema; induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells at 100 µM; reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model |
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| Size | 250 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD 271 |
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| Gene, Accession, CAS # | CAS: 106685-40-9 |
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| Catalog # | 13655-250 |
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| Price | |
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| Order / More Info | Adapalene from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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