| 产品详情 |
| Edit |   |
|---|
| Product Name | AGN 193109 (sodium salt) |
|---|
| Description | A pan-RAR antagonist (Kd = 2, 2, and 3 nM for RARα, β, and γ, respectively); selective for RARs over RXRs (Kd = >10,000 nM for human RXRα, β, and γ receptors); reverses TTNPB-induced changes in cell morphology in ECE16-1 cells; reverses the growth suppressive effects of all-trans-RA, 13-cis-RA, and 9-cis-RA in ECE16-1 cells when used at a 10-fold molar excess; decreases expression of cytokeratin K5-8, 13, 14, 16, 17, and 19 genes, markers of retinoid action in ECE16-1 cells, when co-administered with TTNPB, but not when used alone; induces cleft palate or frontonasal dysplasia and eye malformations in fetuses of pregnant mice following a single oral dose of 1 mg/kg |
|---|
| Size | 500 µg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | CD3106 |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 23975-500 |
|---|
| Price | |
|---|
| Order / More Info | AGN 193109 (sodium salt) from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|