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| Antigenic Specificity | Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) |
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| Clone | 10F6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | ascites |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ELISA,Flow Cytometry (FACS),Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues. |
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| Immunogen | Purified recombinant fragment of human ITGA5 expressed in E. coli. |
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| Other Names | ITGA5|Cd49e|Fnra|VLA5|CD49e|FNRA|VLA5A|Itga5_retired |
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| Gene, Accession # | Gene ID: 3678 |
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| Catalog # | ABIN969221 |
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| Order / More Info | Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 7504269, 9864377, 10982404, 11149921, 11893752 |
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