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| Product Name | Recombinant Streptococcus pneumoniae serotype 2 Pneumolysin (ply) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 72.8kDa. Full Length of Mature Protein: 2-471aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466). Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Thiol-activated cytolysin |
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| Gene, Accession, CAS # | ply, UniProt: Q04IN8 |
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| Catalog # | RPC22369 |
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| Order / More Info | Recombinant Streptococcus pneumoniae serotype 2 Pneumolysin (ply) from BIOMATIK |
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| Product Specific References | n/a |
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