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| Product Name | Recombinant Streptococcus pneumoniae serotype 4 Pneumolysin (ply) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 68.8kDa. Full Length of Mature Protein: 2-471aa. N-terminal 6xHis-SUMO-tagged. Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4). Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host mbranes. After binding to target mbranes, the protein undergoes a major conformation change, leading to its insertion in the host mbrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host mbranes, mbrane insertion and pore formation. Can be reversibly inactivated by oxidation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Thiol-activated cytolysin |
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| Gene, Accession, CAS # | ply, UniProt: P0C2J9 |
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| Catalog # | RPC20106 |
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| Order / More Info | Recombinant Streptococcus pneumoniae serotype 4 Pneumolysin (ply) from BIOMATIK |
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| Product Specific References | n/a |
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