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| Product Name | Recombinant Human AT-rich interactive domain-containing protein 1A (ARID1A), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 32.4kDa. Partial: 1976-2231aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | B120; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A; Osa homolog 1; hOSA1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; hELD; C1orf4, OSA1, SMARCF1 |
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| Gene, Accession, CAS # | ARID1A, UniProt: O14497 |
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| Catalog # | RPC26317 |
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| Order / More Info | Recombinant Human AT-rich interactive domain-containing protein 1A (ARID1A), partial from BIOMATIK |
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| Product Specific References | n/a |
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