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| Product Name | Recombinant Human 2-5A-dependent ribonuclease |
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| Description | 330-741aa; Partial. MW: 63.4kD. Purity >90% as determined by SDS-PAGE. Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stres |
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| Size | 0.05 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli), 1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Ribonuclease 4; Ribonuclease L; RNase L] |
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| Gene, Accession, CAS # | RNASEL, Gene ID: 6041, Accession: NP_066956.1 |
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| Catalog # | MBS969669 |
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| Order / More Info | Recombinant Human 2-5A-dependent ribonuclease from MYBIOSOURCE INC. |
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| Product Specific References | Expression cloning of 2-5A-dependent RNAasea uniquely regulated mediator of interferon action.Zhou A., Hassel B.A., Silverman R.H.Cell 72:753-765(1993) Analysis and origins of the human and mouse RNase L genesmediators of interferon action.Zhou A., Nie H., Silverman R.H.Mamm. Genome 11:989-992(2000) The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoer |
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