| 产品详情 |
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| Product Name | Recombinant Human B-cell receptor CD22 (CD22), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 79.1kDa. Extracellular Domain: 20-687aa. C-terminal 6xHis-tagged. Homo sapiens (Human). Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | B-lymphocyte cell adhesion molecule (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD22) (SIGLEC2) |
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| Gene, Accession, CAS # | CD22, UniProt: P20273 |
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| Catalog # | RPC26431 |
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| Order / More Info | Recombinant Human B-cell receptor CD22 (CD22), partial from BIOMATIK |
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| Product Specific References | n/a |
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