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| Product Name | SGC 0946 |
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| Description | Highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1. To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.. Purity 99%. MW (observed): 618.57 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 4541/10 |
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| Price | |
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| Order / More Info | SGC 0946 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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