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| Product Name | Recombinant Human Breast cancer metastasis-suppressor 1 |
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| Description | 1-235aa; Partial. MW: 54.7kD. Purity >90% as determined by SDS-PAGE. Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis |
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| Size | 0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [breast cancer metastasis-suppressor 1 isoform 1; Breast cancer metastasis-suppressor 1; breast cancer metastasis-suppressor 1; breast cancer metastasis suppressor 1] |
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| Gene, Accession, CAS # | BRMS1, Gene ID: 25855, Accession: NP_056214.1 |
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| Catalog # | MBS717381 |
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| Order / More Info | Recombinant Human Breast cancer metastasis-suppressor 1 from MYBIOSOURCE INC. |
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| Product Specific References | Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13.Seraj M.J., Samant R.S., Verderame M.F., Welch D.R.Cancer Res. 60:2764-2769(2000) Genomic structure and chromosomal localization of the breast metastasis suppressor gene, BRMS1.Welch D.R., Samant R.S., Debies M.T., Seraj M.J., Verderame M.F. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression.Rivera J., Megias D., Bravo J.J. Cel |
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