| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | PKM2 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse, rat, human |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 50 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Pyruvate kinase, a glycolytic enzyme, catalyses the conversion of phosphoenolpyruvate to pyruvate. In mammals, the M1 isoform (PKM1) is expressed in most adult tissues . The M2 isoform (PKM2), an alternatively-spliced variant of M1, is expressed during embryonic development . Studies found that cancer cells exclusively express PKM2 . PKM2 is shown to be essential for aerobic glycolysis in tumors (Warburg effect) . When the M2 isoform is switched to the M1 isoform, aerobic glycolysis is reduced and oxidative phosphorylation is increased in cancer cells . These cells also show decreased tumorigenicity in mouse xenografts . Recent studies show that the oncogenic forms of FGFR1 directly phosphorylate Tyr105 of PKM2 and thereby inhibit the formation of active tetrameric PKM2 . A PKM2 mutant found in cancer cells, in which Tyr105 is replaced by phenylalanine, leads to reduced cell proliferation in hypoxia and tumor growth in xenografts in nude mice . These findings suggest that the phosphorylation at Tyr105 is a critical switch for the metabolism in cancer cells that promotes tumor growth . Synonyms: PKM2 , TCB, PK3,PKM2 pyruvate kinase, muscle, CTHBP, PK2 |
|---|
| Immunogen | Recombinant Protein of human PKM2 |
|---|
| Other Names | PKM2|CTHBP|OIP3|PK3|TCB|THBP1|AA414905|AL024370|AL024424|Pk-2|Pk-3|Pk3|Pkm2|PKM12|PK-S|PKM|pk3|pkm2|cb1029|fj33f03|pkm2a|wu:fj33f03 |
|---|
| Gene, Accession # | Gene ID: 5315,18746,25630 |
|---|
| Catalog # | ABIN1683871 |
|---|
| Price | |
|---|
| Order / More Info | PKM2 Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|