| 产品详情 |
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| Antigenic Specificity | Tumor Protein P53 (TP53) (aa 378-393), (pSer392) |
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| Clone | FP3-2 [FPS392] |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein A purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. |
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| Immunogen | KLH-conjugated phosphopeptide RHKKLMFKTEGPDS[P]D, corresponding to amino acids 378-393 of human p53. |
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| Other Names | tp53|p53|TP53|Tp53|bbl|bfy|bhy|p44|TpMs|BCC7|LFS1|P53|TRP53|Trp53|Xp53|brp53|drp53|etID22686.5|fb40d06|wu:fb40d06|zgc:111919 |
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| Gene, Accession # | Gene ID: 7157 |
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| Catalog # | ABIN94450 |
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| Price | |
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| Order / More Info | Tumor Protein P53 (TP53) (aa 378-393), (pSer392) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 10951576, 9843965, 18323654, 9927185, 10564259, 7667317 |
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