| Edit |   |
|---|
| Antigenic Specificity | CCND2 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse |
|---|
| Isotype | n/a |
|---|
| Format | peptide affinity purified |
|---|
| Size | 400 ul |
|---|
| Concentration | n/a |
|---|
| Applications | WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Rabbit polyclonal to CCND2. Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). |
|---|
| Immunogen | This Mouse CCND2 Antibody Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-289 amino acids from the C-term region of mouse CCND2. |
|---|
| Other Names | Ccnd2, Cyl-2, G1/S-specific cyclin-D2 |
|---|
| Gene, Accession # | UniProt: Q04827 |
|---|
| Catalog # | orb107016 |
|---|
| Price | |
|---|
| Order / More Info | CCND2 Antibody from BIORBYT LTD. |
|---|
| Product Specific References | n/a |
|---|