| 产品详情 |
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| Antigenic Specificity | RIC8B |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rabbit, human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Mouse RIC8B polyclonal antibody for WB, IP. Synembryn-B (UniProt Q80XE1; also known as Protein Ric-8B, Resistance to inhibitors of cholinesterase 8B) is encoded by the Ric8b (also known as BC051080) gene (Gene ID 237422) in murine species. Ric-8A and Ric-8B stimulate nucleotide exchange of all Gα subunit classes by stabilizing the Gα nucleotide-free transition state. Ric-8A acts upon Gαi/q/13, while Ric-8B targets Gαs/olf. In addition to their function as guanine nucleotide exchange factors (GEFs), Ric proteins also act as molecular chaperones that directly participate in the posttranslational folding of nascent Gα subunits to promote G-protein biosynthesis and membrane association. Ric-8 knockdown reduces Gα steady-state abundances and overexpression of Ric-8 proteins enhances cellular Gα levels. In Ric-8A- or Ric-8B-delicient ES cells, newly produced Gα subunits are defective in the initial association with an internal membrane, resulting in a ?10-fold faster turned over rate than in WT cells. |
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| Immunogen | Recombinant Protein |
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| Other Names | n/a |
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| Gene, Accession # | UniProt: Q80XE1 |
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| Catalog # | CABT-B1649 |
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| Price | |
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| Order / More Info | RIC8B Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 产品资料 |
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