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| Antigenic Specificity | Human BACE (C-terminal, aa 485-501) |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, IHC, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Goat Anti-Human BACE (C-terminal) polyclonal antibody for ELISA, IHC, WB. Alzheimer`s disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid β-peptide (Aβ). Aβ generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Aβ by β-secretase. The Aβ peptide is then released by proteolytic cleavage at its C-terminus by 8-secretase. Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes. β-secretase is a transmembrane aspartic-protease (Asp2), referred to as BACE or memapsin 2, has been characterized and shown to have all the properties of β-secretase. Four groups in all have now confirmed that BACE (or memapsin 2) is a convincing candidate for β-secretase. |
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| Immunogen | Peptide (CLRQQHDDFADDISLLK) |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 23621, UniProt: P56817 |
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| Catalog # | CABT-L524 |
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| Price | |
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| Order / More Info | Human BACE (C-terminal, aa 485-501) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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