| 产品详情 |
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| Antigenic Specificity | Cyclin D2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | lyophilized |
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| Applications | Western Blot: Assay-dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cyclin D2 Polyclonal Antibody. Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, |
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| Immunogen | n/a |
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| Other Names | G1/S-specific cyclin-D2, CCND2 |
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| Gene, Accession # | Entrez: 12444, 64033, 894; Uniprot: P30279, P30280, Q04827 |
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| Catalog # | PA5-78942 |
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| Price | |
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| Order / More Info | Cyclin D2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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