| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | KEAP1 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse, rat |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 ug |
|---|
| Concentration | n/a |
|---|
| Applications | Immunofluorescence: 20 µg/mL, Western Blot: 1-2 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | KEAP1 Polyclonal Antibody. KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-Kappa-B activity by targeting IKKBeta degradation. Mutation of the KEAP1 gene is found in lung ca |
|---|
| Immunogen | n/a |
|---|
| Other Names | KEAP1, Kelch-like ECH-associated protein 1, INRF2, Kelch-like protein 19, KLHL19, Cytosolic inhibitor of NRF2 |
|---|
| Gene, Accession # | Entrez: 117519, 50868, 9817; Uniprot: P57790, Q14145, Q9Z2X8 |
|---|
| Catalog # | PA5-34454 |
|---|
| Price | |
|---|
| Order / More Info | KEAP1 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|