| 产品详情 |
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| Antigenic Specificity | BARD1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:200 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BARD1 Polyclonal Antibody. This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This prot |
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| Immunogen | n/a |
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| Other Names | BRCA1-associated RING domain protein 1; BARD-1; BARD 1 |
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| Gene, Accession # | Entrez: 12021, 580, 64557; Uniprot: O70445, Q99728, Q9QZH2 |
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| Catalog # | PA5-75304 |
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| Price | |
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| Order / More Info | BARD1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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