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| Antigenic Specificity | Kindlin 3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Kindlin 3 Polyclonal Antibody. The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in |
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| Immunogen | n/a |
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| Other Names | KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF; MIG2-like protein; UNC-112 related protein 2; fermitin family homolog 3; kindlin 3; unc-112-related protein 2 |
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| Gene, Accession # | Entrez: 83706; Uniprot: Q86UX7 |
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| Catalog # | PA5-66753 |
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| Price | |
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| Order / More Info | Kindlin 3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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