| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Phospho-IKK alpha/beta (Ser176, Ser180) |
|---|
| Clone | 7H17L17 |
|---|
| Host Species | Recombinant Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Phospho-IKK alpha/beta (Ser176, Ser180) Antibody (7H17L17), ABfinity™ Rabbit Monoclonal. Ikk alpha/beta is encoded by CHUk (conserved helix-loop-helix ubiquitous kinase) and Ikk B (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF- kB pathway such as TNF alpha, the two subunits of Ikk complex, Ikk alpha and Ikk beta alongside a regulator NEMO (Ikk gamma) phosphorylates I-kappa-B proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation c |
|---|
| Immunogen | n/a |
|---|
| Other Names | IKKA, TCF17 |
|---|
| Gene, Accession # | Entrez: 1147, 3551; Uniprot: O14920, O15111 |
|---|
| Catalog # | 701643 |
|---|
| Price | |
|---|
| Order / More Info | Phospho-IKK alpha/beta (Ser176, Ser180) Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|