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| Antigenic Specificity | Phospho-IKK alpha/beta (Ser176, Ser180) |
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| Clone | 7HCLC |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-IKK alpha/beta (Ser176, Ser180) Antibody (7HCLC), ABfinity™ Rabbit Oligoclonal. IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change th |
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| Immunogen | n/a |
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| Other Names | IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, I-kappa-B kinase 1, I-kappa-B kinase-alpha, IKK-a kinase, IkB kinase alpha subunit, TCF-16 subunit alpha, transcription factor 16, IKK-beta, IKK2, IKKB, NFKBIKB, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, inhibitor of nuclear factor kappa-B kinase subunit beta, nuclear factor NF-kappa-B inhibitor kinase beta |
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| Gene, Accession # | Entrez: 1147, 3551; Uniprot: O14920, O15111 |
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| Catalog # | 710676 |
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| Price | |
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| Order / More Info | Phospho-IKK alpha/beta (Ser176, Ser180) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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