| 产品详情 |
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| Antigenic Specificity | PYCARD |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA: 1:40,000, Immunocytochemistry: 1:200-1:1000, Immunofluorescence: 1:200-1:1000, Immunohistochemistry: 1:100-1:300, Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PYCARD Polyclonal Antibody. Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In inna |
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| Immunogen | n/a |
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| Other Names | ASC, CARD5, TMS1 |
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| Gene, Accession # | Entrez: 282817, 29108, 66824; Uniprot: Q9EPB4, Q9ULZ3 |
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| Catalog # | PA5-50915 |
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| Price | |
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| Order / More Info | PYCARD Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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