| 产品详情 |
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| Antigenic Specificity | TAB1 |
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| Clone | F.211.6 |
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| Host Species | Rabbit |
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| Reactive Species | human, nonhuman primate |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TAB1 Monoclonal Antibody (F.211.6). The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an a |
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| Immunogen | n/a |
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| Other Names | TAK1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1; transforming growth factor beta-activated kinase-binding protein 1 |
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| Gene, Accession # | Entrez: 10454; Uniprot: Q15750 |
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| Catalog # | MA5-14964 |
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| Price | |
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| Order / More Info | TAB1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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