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| Product Name | Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial |
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| Description | 763-931aa, Partial. MW: 46.4kDa. Purity >90% as determined by SDS-PAGE. Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Insulin-like growth factor I receptor ;IGF-I receptor; CD221] |
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| Gene, Accession, CAS # | IGF1R, Gene ID: 3480, Accession: NP_000866.1 |
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| Catalog # | MBS961761 |
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| Order / More Info | Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial from MYBIOSOURCE INC. |
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| Product Specific References | Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.Buchanan J.L., Newcomb J.R., Carney D.P., Chaffee S.C., Chai L., Cupples R., Epstein L.F., Gallant P., Gu Y., Harmange J.C., Hodge K., Houk B.E., Huang X., Jona J., Joseph S., Jun H.T., Kumar R., Li C. , Lu J., Menges T., Morrison M.J., Novak P.M., van der Plas S., Radinsky R., Rose P.E., Sawant S., Sun J.R., Surapaneni S., Turci S.M., Xu K., Yanez E., Zhao H., Zhu X.Bioorg. Med. Chem. Let |
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