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| Product Name | PS 1145 dihydrochloride |
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| Description | Selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active. Purity 98%. MW (observed): 395.67 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride |
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| Gene, Accession, CAS # | CAS: 1049743-58-9 |
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| Catalog # | 4569/10 |
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| Order / More Info | PS 1145 dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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