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| Product Name | WM852 Non-Viable Cell Pellet (Bulk) |
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| Description | Non-viable cell pellet was generated from cell line WM852. WM852 is a metastaic melanoma cell line with epithelial morphology. This cell line was established from the metastatic site (abdomen) in a 63-year -old male. This cell line contains a Q61R mutation at position 61 in the N-RAS gene. The Q61R is the most common NRAS mutation found in melanoma that is thought to occur due to UV and radiation exposure. This mutation leads to production of a constitutively active N-RAS protein that directs cells to grow and divide constantly. This cell line also expresses PTEN loss of function including hemizygous deletion and is wild type for BRAF, c-KIT and CDK4. WM852 cells produce xenograft tumors when injected into immunocompromised mice. |
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| Size | 1 each |
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| Concentration | n/a |
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| Applications | Frozen non-viable cell pellets can be used for in vitro experiments such as Western blotting and other immunoassays, genomic DNA isolation, STR profiling, and RNA isolation. |
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| Other Names | Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | WM852-03-Bulk |
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| Order / More Info | WM852 Non-Viable Cell Pellet (Bulk) from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | Friedegund Meier et al. Human Melanoma Progression in Skin Reconstructs: Biological Significance of bFGF. Am J Pathol. (2000); 156(1): 193-200. doi: 10.1016/S0002-9440(10)64719-10 |
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