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| Product Name | Recombinant Human PAI-1 Protein |
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| Description | Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFα, glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases. Accordingly, PAI-1 has been implicated as an important molecular link between obesity and coronary disease. PAI-1 can also specifically bind vitronectin (VTN) to form a stable active complex with an increased circulatory half life relative to free PAI-1. Recombinant human PAI-1 is a 42.7 kDa protein containing 379 amino acid residues. |
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| Size | Various Sizes |
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| Concentration | n/a |
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| Applications | Cell Culture |
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| Other Names | Plasminogen activator inhibitor 1;PAI;PAI-1;Endothelial plasminogen activator inhibitor;Serpin E1;SERPINE1;PAI1, PLANH1; Plasminogen Activator Inhibitor-1, Serpin E1 |
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| Gene, Accession, CAS # | SERPINE1, UniProt: P05121 |
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| Catalog # | PROTP05121-2 |
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| Order / More Info | Recombinant Human PAI-1 Protein from BOSTER BIO |
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| Product Specific References | n/a |
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