| 产品详情 |
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| Antigenic Specificity | NPM1 |
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| Clone | 1042CT5.2.1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | peptide affinity purified |
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| Size | 400 ul |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse monoclonal to NPM1. Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. |
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| Immunogen | Purified His-tagged NPM1 protein was used to produced this monoclonal antibody. |
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| Other Names | NPM1, NPM, Nucleophosmin, Nucleophosmin, Nucleolar phosphoprotein B23, Nucleophosmin, Nucleolar protein NO38, Nucleophosmin, Numatrin |
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| Gene, Accession # | n/a |
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| Catalog # | orb106886 |
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| Price | |
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| Order / More Info | NPM1 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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| 产品资料 |
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