| 产品详情 |
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| Product Name | Recombinant Human M-CSF (carrier-free) |
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| Description | M-CSF was first characterized as a glycoprotein that induces monocyte and macrophage colony formation from precursors in murine bone marrow cultures. M-CSF is constitutively present at biologically active concentrations in human serum. It binds CD14+ monocytes and promotes the survival/proliferation of human peripheral blood monocytes. In addition, M-CSF enhances inducible monocyte functions including phagocytic activity, microbial killing, cytotoxicity for tumor cells as well as synthesis of inflammatory cytokines such as IL-1, TNFα, and INFγ in monocytes. M-CSF induces RANKL production in mature human osteoclasts; consequently, M-CSF is a potent stimulator of mature osteoclast resorbing activity. Also, M-CSF induces VEGF in human monocytes in human tumors; high levels of M-CSF, mononuclear phagocytes, and VEGF are associated with poor prognosis in patients with cancer. High levels of M-CSF have been associated with different pathologies such as pulmonary fibrosis and atherosclerosis. M-CSF binds to its receptor M-CSFR, and this receptor is shared by a second ligand, IL-34. Human M-CSF and IL-34 exhibit cross-species specificity – both bind to human and mouse M-CSF receptors. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | CSF1, CSF-1, MCSF |
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| Gene, Accession, CAS # | Gene ID: 1435 |
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| Catalog # | 574808 |
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| Order / More Info | Recombinant Human M-CSF (carrier-free) from BIOLEGEND |
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| Product Specific References | PubMed: 25335894 |
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