| 产品详情 |
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| Product Name | Recombinant Human EGF Receptor (EGFR) Protein |
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| Description | EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFα, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions. |
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| Size | Various Sizes |
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| Concentration | n/a |
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| Applications | Cell Culture |
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| Other Names | Epidermal growth factor receptor;2.7.10.1;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR;ERBB, ERBB1, HER1; ErbB1 |
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| Gene, Accession, CAS # | EGFR, UniProt: P00533 |
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| Catalog # | PROTP00533-3 |
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| Order / More Info | Recombinant Human EGF Receptor (EGFR) Protein from BOSTER BIO |
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| Product Specific References | n/a |
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