| 产品详情 |
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| Antigenic Specificity | CD95 (APO-1/Fas) |
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| Clone | 15A7 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1 µg/test |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD95 (APO-1/Fas) Monoclonal Antibody (15A7), eBioscience™. CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses. |
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| Immunogen | n/a |
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| Other Names | ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6 |
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| Gene, Accession # | Entrez: 14102; Uniprot: P25446 |
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| Catalog # | 14-0951-85 |
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| Price | |
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| Order / More Info | CD95 (APO-1/Fas) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 19478044, 20505142, 21474645, 21788338, 25917099, 25938788, 26214741, 26426076, 26794038, 27258160, 27335461, 28874817, 29249358, 29555915 |
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