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| Product Name | Recombinant Human Beclin 1-associated autophagy-related key regulator (ATG14) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 60.3kDa. Full Length: 1-492aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Autophagy-related protein 14-like protein; Short name:Atg14L |
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| Gene, Accession, CAS # | ATG14, UniProt: Q6ZNE5 |
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| Catalog # | RPC20400 |
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| Order / More Info | Recombinant Human Beclin 1-associated autophagy-related key regulator (ATG14) from BIOMATIK |
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| Product Specific References | n/a |
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