| 产品详情 |
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| Product Name | NEK6, Active |
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| Description | Nek6 is a serine/threonine kinase that is a member of the Nek family of protein kinases that share an amino-terminal catalytic domain related to NIMA (never in mitosis, gene A) family (1). Nek6 is a nuclear and cytoplasmic kinase that is required for mitotic progression of human cells. Nek6 is phosphorylated and activated during M phase of the cell cycle (2). Inhibition of Nek6 function by either overexpression of an inactive Nek6 mutant or elimination of endogenous Nek6 by siRNA arrests cells in M phase and triggers apoptosis suggesting that Nek6 is required for metaphase-anaphase transition. Nercc1/Nek9 binds to Nek6 and is likely to be responsible for the activation of Nek6 during mitosis representing a new signaling pathway that regulat |
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| Size | 5 µg |
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| Concentration | 5µg/50 µl |
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| Applications | RUO |
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| Other Names | NEK, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek6, Never in mitosis A-related kinase 6, NimA-related protein kinase 6, Protein kinase SID6-1512 |
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| Gene, Accession, CAS # | NEK6, Gene ID: 10783, Accession: Q9HC98 |
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| Catalog # | 7716-5 |
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| Price | |
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| Order / More Info | NEK6, Active from BIOVISION, INC. |
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| Product Specific References | n/a |
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