| 产品详情 |
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| Antigenic Specificity | CD5 Antigen (CD5) |
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| Clone | B19-1 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 0.5 mg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD5/Lyt-1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. |
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| Immunogen | n/a |
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| Other Names | Ly-1|Ly-12|Ly-A|Lyt-1 |
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| Gene, Accession # | Gene ID: 12507 |
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| Catalog # | ABIN135106 |
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| Price | |
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| Order / More Info | CD5 Antigen (CD5) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 8943203, 398327, 3081630 |
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