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| Product Name | Recombinant Human F-box/WD repeat-containing protein 7 (FBXW7) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 83.7kDa. Full Length: 1-707aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Archipelago homolog1 Publication; hAgo1 Publication; F-box and WD-40 domain-containing protein 7Curated; F-box protein FBX301 Publication; SEL-101 Publication; hCdc4 |
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| Gene, Accession, CAS # | FBXW7, UniProt: Q969H0 |
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| Catalog # | RPC20817 |
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| Order / More Info | Recombinant Human F-box/WD repeat-containing protein 7 (FBXW7) from BIOMATIK |
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| Product Specific References | n/a |
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