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| Product Name | Recombinant Human Cyclin-dependent kinase inhibitor 1 (CDKN1A) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 45kDa. Full Length of Mature Protein: 2-164aa. N-terminal GST-tagged. Homo sapiens (Human). May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assbly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | CDK-interacting protein 1Melanoma differentiation-associated protein 6; MDA-6p21 |
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| Gene, Accession, CAS # | CDKN1A, UniProt: P38936 |
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| Catalog # | RPC21075 |
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| Order / More Info | Recombinant Human Cyclin-dependent kinase inhibitor 1 (CDKN1A) from BIOMATIK |
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| Product Specific References | n/a |
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