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| Product Name | Recombinant Human IL-17A (Animal-Free) |
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| Description | IL-17A was initially identified from a subtracted cDNA library between closely related murine lymphoid cells and called CTLA-8, It also shares 58% homology with an open reading frame of the T-lymphotropic Herpesvirus Samirii virus (viral IL-17). IL-17A belongs to a family of cytokines, which has six members; designated IL-17A-F. IL-17 is expressed by a unique lineage of CD4+ T cells (Th17) that develop in response to IL-23, in particular under conditions in which Th1 and Th2 development are suppressed. IL-17A shares the greatest homology (55%) with IL-17F. Both IL-17A and IL-17F are produced by Th17 cells. IL-17A and IL-17F can either exist as IL-17A homodimers and IL-17F homodimers or as IL-17A-IL-17F heterodimers. IL-17 is a key mediator of autoimmune disorders, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, and asthma, and plays a role in host defense. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin-17A (IL-17A), CTLA8 |
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| Gene, Accession, CAS # | Gene ID: 3605 |
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| Catalog # | 716004 |
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| Order / More Info | Recombinant Human IL-17A (Animal-Free) from BIOLEGEND |
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| Product Specific References | n/a |
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