| 产品详情 |
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| Antigenic Specificity | KSHV ORF45 |
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| Clone | 2D4A5 |
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| Host Species | Mouse |
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| Reactive Species | n/a |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ELISA,Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions |
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| Immunogen | Purified recombinant fragment of KSHV ORF45 expressed in E. coli. |
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| Other Names | Kaposi's Sarcoma-associated Herpesvirus (KSHV) |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN969254 |
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| Price | |
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| Order / More Info | KSHV ORF45 Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 7997879, 11943871, 14576556, 12634379 |
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