| 产品详情 |
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| Antigenic Specificity | Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (aa 1-907) |
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| Clone | 5H11 |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 1 mL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry (ICC),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PARP-10. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling. |
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| Immunogen | Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag. |
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| Other Names | ARTD10|PARP10 |
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| Gene, Accession # | Gene ID: 84875 |
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| Catalog # | ABIN2745553 |
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| Price | |
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| Order / More Info | Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (aa 1-907) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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