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| Product Name | Recombinant Human Fibroblast growth factor 2 protein (FGF2) (Active) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 46.3kDa. Extracellular Domain: 20-191aa. C-terminal FC-tagged. Mus musculus (Mouse). T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; Timd3 |
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| Gene, Accession, CAS # | Havcr2, UniProt: Q8VIM0 |
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| Catalog # | RPC26980 |
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| Order / More Info | Recombinant Human Fibroblast growth factor 2 protein (FGF2) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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