| 产品详情 |
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| Product Name | GSK-J4 (Free base) |
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| Description | GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 µM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. MW: 417.5. Purity ≥99% by TLC |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester |
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| Gene, Accession, CAS # | CAS: 1373423-53-0 |
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| Catalog # | 2762-1 |
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| Order / More Info | GSK-J4 (Free base) from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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