| 产品详情 |
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| Product Name | GSK-J4 (Free base) |
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| Description | MW: 417.5. Purity ≥99% by TLC. Background: GSK- J4 is cell-permeable ethyl ester of GSK-J1. Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC?? = 9 muM for the inhibition of TNFalpha release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. |
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| Size | 1 mg, 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine ethyl ester] |
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| Gene, Accession, CAS # | CAS: 1373423-53-0 |
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| Catalog # | MBS843306 |
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| Order / More Info | GSK-J4 (Free base) from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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