| 产品详情 |
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| Antigenic Specificity | TREM-2 |
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| Clone | 6E9 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b |
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| Format | purified |
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| Size | 1 ml |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-TREM-2. TREM-2 is a 26 kD transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. |
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| Immunogen | This monoclonal antibody was raised against a mouse recombinant TREM-2 protein. |
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| Other Names | Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, triggering receptor expressed on monocytes 2, MRT-5093-1000 |
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| Gene, Accession # | Gene ID: 83433 |
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| Catalog # | 824801 |
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| Price | |
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| Order / More Info | TREM-2 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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