| 产品详情 |
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| Antigenic Specificity | CATSPER1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CATSPER1 Polyclonal Antibody. Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. |
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| Immunogen | n/a |
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| Other Names | Cation channel sperm-associated protein 1, CatSper1, hCatSper, CATSPER1 |
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| Gene, Accession # | Entrez: 117144; Uniprot: Q8NEC5 |
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| Catalog # | PA5-48491 |
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| Price | |
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| Order / More Info | CATSPER1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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