| 产品详情 |
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| Product Name | BC-1215 |
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| Description | An inhibitor of FBXO3 (IC50 = 0.9 µg/mL for Il-1β release); decreases FBXO3-FBXL2 interaction in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2; lowers expression of TRAF1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated PBMCs; reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis when administered at a dose of 100 µg, i.p., per animal; reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema, |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BC1215 Fbxo-3 FBX-L2 IL6 IL1β IL1B traf1 traf2 traf3 traf4 traf5 traf6 |
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| Gene, Accession, CAS # | CAS: 1507370-20-8 |
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| Catalog # | 21964-5 |
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| Order / More Info | BC-1215 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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