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| Product Name | Recombinant Human C-C motif chemokine 5 protein (CCL5) (Active) |
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| Description | Purity > 98% as determined by SDS-PAGE and HPLC. MW: 7.8kDa. Full Length of Mature Protein: 24-91aa. tag-Free. Homo sapiens (Human). Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES (3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES (4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES (1-68) and RANTES (3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485). {ECO:0000269|PubMed:1380064, ECO:0000269|PubMed:15923218, ECO:0000269|PubMed:16791620, ECO:0000269|PubMed:17001303, ECO:0000269|PubMed:23979485, ECO:0000269|PubMed:8525373, ECO:0000269|PubMed:9516414}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | EoCP, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228, TCP228 |
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| Gene, Accession, CAS # | CCL5,D17S136E,SCYA5, UniProt: P13501 |
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| Catalog # | RPC26589 |
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| Order / More Info | Recombinant Human C-C motif chemokine 5 protein (CCL5) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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